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METHOTREXATE (Methotrexate Preservative-Free Vial) Description


Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis.

Chemically methotrexate is N-[4-[[(2,4-diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic acid.

The structural formula is:

structural formula methotrexate

                                              Molecular weight: 454.45                      C20H22N8O5

Methotrexate Injection, USP is sterile and non-pyrogenic and may be given by the intramuscular, intravenous or intra-arterial route. (See DOSAGE AND ADMINISTRATION.) The preserved formulation contains benzyl alcohol; do not use for intrathecal or high-dose therapy.

Methotrexate Injection, USP, Isotonic Liquid, Preservative Free, for single use only, is available in 25 mg/mL, 40 mL (1 g) vials.

Each 25 mg/mL, 40 mL vial contains methotrexate sodium equivalent to 1 g methotrexate and the following inactive ingredients: Sodium Chloride 0.490% w/v. Sodium Hydroxide and, if necessary, Hydrochloric Acid are added to adjust the pH to approximately 8.5.

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