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METHOTREXATE (Methotrexate Vial) Description

DESCRIPTION

Methotrexate (formerly Amethopterin) is an antimetabolite used in the treatment of certain neoplastic diseases, severe psoriasis, and adult rheumatoid arthritis.

Chemically methotrexate is N-[4-[[(2,4-diamino-6-pteridinyl) methyl]methylamino]benzoyl]-L-glutamic acid.

The structural formula is:

Methotrexate Structural Formula

Methotrexate Injection, USP is sterile and non-pyrogenic and may be given by the intramuscular, intravenous or intra-arterial route. (See DOSAGE AND ADMINISTRATION.) The preserved formulation contains benzyl alcohol; do not use for intrathecal or high-dose therapy.

Methotrexate Injection, USP, Isotonic Liquid, Contains Preservative is available in 25 mg/mL, 2 mL (50 mg) vials.

Each 25 mg/mL, 2 mL vial contains methotrexate sodium equivalent to 50 mg methotrexate, 0.9% w/v of Benzyl Alcohol as a preservative, and the following inactive ingredients: Sodium Chloride 0.260% w/v and Water for Injection qs ad 100% v. Sodium Hydroxide and, if necessary, Hydrochloric Acid are added to adjust the pH to approximately 8.5.

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